Baclofen

MeSH ID: D001418

DEFINITION: A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist at GABA-B receptors (RECEPTORS, GABA-B). It is used in the treatment of spasticity, especially that due to spinal cord damage. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Related Concepts:

• Baclofen [M0002117]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Baclofen [T004124]
  • Baclophen [T004131]
  • beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid [T004130]
  • beta-(p-Chlorophenyl)-gamma-aminobutyric Acid [T004127]
  • GABA, Chlorophenyl [T004125]
  • PCP-GABA [T004128]
• PMS-Baclofen [M0454548]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • PMSBaclofen [T552575]
  • Baclofen Pharmascience Brand [T552576]
• Nu-Baclo [M0454547]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • NuBaclo [T552573]
  • Nu Pharm Brand of Baclofen [T552574]
• Lioresal [M0002118]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Lioresal [T004132]
  • Ciba Geigy Brand of Baclofen [T552569]
  • Lior�sal [T552572]
  • Baclofen Medtronic Brand [T552570]
  • Baclofen Novartis Brand [T552571]
• Lebic [M0454549]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Lebic [T552577]
  • Baclofen Isis Brand [T552578]
• Gen-Baclofen [M0454550]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • GenBaclofen [T552579]
  • Genpharm [T552580]
• Clofen [M0454551]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Clofen [T552581]
  • Baclofen Alphapharm Brand [T552582]
• Baclospas [M0454552]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Baclospas [T552583]
  • Baclofen Ashbourne Brand [T552584]
• Baclof�ne-Irex [M0454553]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Baclof�neIrex [T552585]
  • Baclofen Irex Brand [T552586]
• Baclofen AWD [M0454556]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • AWD, Baclofen [T552591]
  • ASTA Medica Brand of Baclofen [T552592]
• Ba-34,647 [M0351459]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Ba34,647 [T004123]
  • Ba34647 [T004129]
  • CIBA34,647BA [T004126]
• Atrofen [M0454554]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • Atrofen [T552587]
  • Baclofen Athena Brand [T552588]
• Apo-Baclofen [M0454555]
  Concept Semantic Types:
  • Pharmacologic Substance [T121]
  • Amino Acid, Peptide, or Protein [T116]
  Concept Terms:
  • ApoBaclofen [T552589]
  • Baclofen Apotex Brand [T552590]

Qualifiers:

administration & dosage [Q000008] ; adverse effects [Q000009] ; agonists [Q000819] ; analogs & derivatives [Q000031] ; analysis [Q000032] ; antagonists & inhibitors [Q000037] ; blood [Q000097] ; cerebrospinal fluid [Q000134] ; chemical synthesis [Q000138] ; chemistry [Q000737] ; classification [Q000145] ; contraindications [Q000744] ; diagnostic use [Q000176] ; economics [Q000191] ; history [Q000266] ; immunology [Q000276] ; isolation & purification [Q000302] ; metabolism [Q000378] ; pharmacokinetics [Q000493] ; pharmacology [Q000494] ; poisoning [Q000506] ; radiation effects [Q000528] ; standards [Q000592] ; supply & distribution [Q000600] ; therapeutic use [Q000627] ; toxicity [Q000633] ; urine [Q000652]

Tree Structure:

• Chemicals and Drugs [D ]
  • Organic Chemicals [D02 , D009930]
    • Carboxylic Acids [D02.241 , D002264]
      • Acids, Acyclic [D02.241.081 , D000144]
        • Butyric Acids [D02.241.081.160 , D002088]
          • Aminobutyric Acids [D02.241.081.160.050 , D000613]
            • gamma-Aminobutyric Acid [D02.241.081.160.050.350 , D005680]
              • Baclofen [D02.241.081.160.050.350.100, D001418]

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