Experimental Model of Disease

MeSH ID: T050

Related Concepts:

  • Alloxan Diabetes [M0006149]
  • Arthritis, Adjuvant-Induced [M0375528]
    An experimental model of arthritis that is induced by injecting adjuvants. These adjuvants generally consists of a mixture of light paraffin oil, emulsifying agent, and infective agents or antigens, such as killed mycobacteria or bacterial lipopolysaccharides.
  • Arthritis, Collagen-Induced [M0375531]
    An experimental model of arthritis that is induced by injecting COLLAGEN to stimulate the immune response.
  • Arthritis, Experimental [M0001743]
    ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
  • Autoimmune Myositis, Experimental [M0334361]
  • Avian Leukosis [M0002025]
    A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere.
  • Carcinoma 256, Walker [M0003430]
    A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
  • Carcinoma, Ehrlich Tumor [M0003437]
    A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
  • Carcinoma, Krebs 2 [M0003438]
  • Carcinoma, Lewis Lung [M0028181]
    A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
  • Diabetes Mellitus, Experimental [M0006150]
    Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
  • Disease Models, Animal [M0006565]
    Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
  • Encephalomyelitis, Autoimmune, Experimental [M0007370]
    An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
  • Experimental Autoimmune Myasthenia Gravis, Passive Transfer [M0334367]
  • Experimental Hepatoma [M0012656]
  • Experimental High Pressure Neurological Syndrome [M0335278]
  • Experimental Lung Inflammation [M0357615]
  • Experimental Pneumococcal Meningitis [M0335674]
  • Experimental Spinal Cord Ischemia [M0336092]
  • Hepatoma, Morris [M0012653]
  • Hepatoma, Novikoff [M0012654]
  • Hypokinesia, Experimental [M0337107]
  • Leukemia L1210 [M0012383]
  • Leukemia L5178 [M0012384]
    An experimental lymphocytic leukemia of mice.
  • Leukemia P388 [M0012385]
    An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
  • Leukemia, Experimental [M0012386]
    Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
  • Liver Cirrhosis, Experimental [M0012642]
    Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
  • Liver Neoplasms, Experimental [M0012655]
    Experimentally induced tumors of the LIVER.
  • Mammary Neoplasms, Experimental [M0012963]
    Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
  • Melanoma, B16 [M0013310]
  • Melanoma, Cloudman S91 [M0013311]
  • Melanoma, Experimental [M0013313]
    Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
  • Melanoma, Harding-Passey [M0013312]
  • Murine Acquired Immunodeficiency Syndrome [M0024700]
    Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.
  • Myasthenia Gravis, Autoimmune, Experimental [M0328219]
    Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
  • Nervous System Autoimmune Disease, Experimental [M0328377]
  • Neuritis, Autoimmune, Experimental [M0014694]
    An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
  • Parkinsonism, Experimental [M0332504]
  • Radiation Injuries, Experimental [M0018383]
    Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
  • Rous Sarcoma [M0002033]
  • Sarcoma 180 [M0019431]
  • Sarcoma 37 [M0019432]
  • Sarcoma, Avian [M0002032]
    Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.
  • Sarcoma, Engelbreth-Holm-Swarm [M0019434]
  • Sarcoma, Experimental [M0019435]
    Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
  • Sarcoma, Jensen [M0019436]
  • Sarcoma, Yoshida [M0019440]
  • Streptozotocin Diabetes [M0006151]
  • Tumor Virus Infections [M0022156]
    Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.